More Views

GUIDOR® easy-graft® CLASSIC Alloplastic Bone Grafting System

The first particulate bone grafting material designed to be syringed directly into a bone defect, hardening into a stable, porous scaffold in approximately one minute and eliminating the need for a dental membrane in many cases.

  • 100% synthetic, fully resorbable and unit-dose application
  • Complete system that eliminates the need to guess with which liquid (e.g. blood, saline) to mix the granules
  • Ideally suited for filling voids around immediate implant placements and ridge preservation after tooth extraction

Each unit contains three systems. A system of GUIDOR easy-graft includes one syringe of coated granules and one ampule of BioLinker®.

* Required Fields

Availability: In stock

Material Composition

GUIDOR® easy-graft® CLASSIC Alloplastic Bone Grafting System is a complete system that helps clinicians provide more predictable clinical results. Each system is comprised of β-tricalcium phosphate (β-TCP) granules coated with a biodegradable polymer called poly(lactide-co-glycolide) (PLGA). that are mixed with N-methyl-2-pyrrolidone (NMP) liquid activator called BioLinker® to form a permeable, moldable material which hardens to form a stable, porous scaffold.

GUIDOR® <i>easy-graft</i>® is comprised of coated granules in a syringe and a liquid activator that is mixed for easy placement.

Step 1: The system contains BioLinker® and β-TCP granules with polymer coating.
Step 2: When mixed, BioLinker softens the polymer coating creating a sticky surface that can be compressed and shaped.
Step 3: BioLinker is flushed out of the material when in contact with body fluids.
Step 4: GUIDOR easy-graft hardens in approximately one minute into a stable, porous scaffold of interconnected granules.

Granule Porosity

The porous nature of the material used in GUIDOR® easy-graft® CLASSIC Alloplastic Bone Grafting System is a key factor for bone regeneration.

Spherical granules of GUIDOR® easy-graft® are beta-TCP coated with PLGA.

β-TCP granule (A) with a polylactide polymer coating (B)1:
To ensure a comprehensive, intact pore system is retained, each pressure-resistant granule is designed to not fragment or crumble during application.

Macroporosity of GUIDOR® easy-graft® formed from spaces between each pressure-resistant granule. Macroporosity of GUIDOR easy-graft material1: Subsequent to mixing and dispensing GUIDOR easy-graft material, macropores will exist in the spaces between the round, pressure-resistant granules. These larger pores provide space for the formation of new bone and the development of blood vessels.
GUIDOR® easy-graft® granules are openly microporous with total porosity of 70%. Microporosity of GUIDOR easy-graft material1: GUIDOR easy-graft material is openly microporous with a total porosity of approximately 70%. When viewing the SEM image, the microporous nature of this bone graft appears as dark areas within each granule. Studies have shown fully microporous calcium phosphates (pore size 1 μm to 10 μm) provide increased osteoconductivity and bone formation in comparison with materials without micropores.2,3


GUIDOR® easy-graft® CLASSIC Alloplastic Bone Grafting System is designed to offer complete resorption via physiological dissolution and cell based mechanisms in 5-15 months, depending upon biological and medical factors. The resorption of the GUIDOR easy-graft (A) occurs in parallel to new bone (B) formation. In the human histology, the granule of GUIDOR easy-graft (A) is no longer spherical in shape as the material resorbs. At the same time, new bone (B) forms and appears to invade the accessible space.4

Courtesy of Dr. Minas Leventis (Athens, Greece) and Dr. Heiner Nagursky (University of Freiburg, Germany).

  1. Scanning electron microscope (SEM) image
  2. Habibovic P., Sees T. M., van den Doel M. A., van Blitterswijk C. A. and de Groot K.: Osteoinduction by biomaterials – physicochemical and structural influences J Biomed Mater Res A ( 2006 ) 77( 4 ): 747-62.
  3. Hing K. A., Annaz B., Saeed S., Revell P. A. and Buckland T.: Microporosity enhances bioactivity of synthetic bone graft substitutes J Mater Sci Mater Med (2005) 16(5): 467-75
  4. Human histology at 4 months after placement of GUIDOR® easy-graft® CLASSIC. Courtesy of Dr. Minas Leventis (Athens, Greece) and Dr. Heiner Nagursky (University of Freiburg, Germany).

A majority of clinicians surveyed said they use GUIDOR® easy-graft® CLASSIC Alloplastic Bone Grafting System because preparation and placement are simpler and faster than other bone graft materials1 and because use of GUIDOR easy-graft does not require a dental membrane in many cases.1

  • Easy-to-handle; syringe directly into the defect
  • Material hardens into a stable, porous scaffold in minutes
  • Ideal for socket preservation and packing around an implant

Animated Technology Overview

Instructions for Use (IFU)

Prior to handling products, clinicians should review the Instructions for Use (IFU) for product information, indications, contraindications, precautions, potential adverse effects, and handling directions.

Instructions for Use - For use with Item # C11-007, C11-008, C11-018, C11-078
Language: English, French, Spanish


GUIDOR® easy-graft® CLASSIC Alloplastic Bone Grafting System is indicated for the treatment of intraoral/maxillofacial osseous defects. Dental and maxillofacial indications may include:

  • Extraction defects (alveolar ridge preservation)
  • Periodontal defects
  • Peri-implant defects
  • Augmentation of deficient alveolar crest (e.g. Guided Bone Regeneration, GBR)
  • Sinus floor augmentation
  • Defects after surgical extractions
  • Defects after removal of bone cysts
  • Defects after root resection or apicoectomy
  • Defects after removal of autologous bone


GUIDOR® easy-graft® CLASSIC Alloplastic Bone Grafting System should not be used in pregnant or nursing women.

Possible Adverse Effects

Possible adverse reactions associated with the use of the device include: eye, respiratory and skin irritation.

Other Supporting Documents

Dentists using GUIDOR easy-graft may find the following documents helpful.

  1. GUIDOR® easy-graft® Customer Satisfaction Survey, February 2014.

If the ability to place an implant is your primary measure of success, GUIDOR® easy-graft® CLASSIC Alloplastic Bone Grafting System provides a predictable way to maintain alveolar bone for rehabilitation with dental implants after tooth extraction.1

Surgical Technique Video

Dr. Minas Leventis demonstrates surgical techniques for minimally invasive ridge preservation.

Case: Ridge Preservation using GUIDOR easy-graft [2:43 minutes]
This surgical video focuses on the clinical steps for minimally invasive ridge preservation procedures. Treatment includes atraumatically extracting the tooth, socket preparation, placement of bone graft material.

Clinical Ridge Preservation Step-by-Step Video

Clinical Presentation

Dr. Robert A. Horowitz and Dr. Sebastiano Andreana highlighted how they successfully leveraged GUIDOR® easy-graft® CLASSIC Alloplastic Bone Grafting System to perform various challenging cases.

These in-depth videos were recorded live at the AAP Corporate Forum in Orlando, Florida in November 2015. Click to see more.

Scientific Publications

GUIDOR® easy-graft® CLASSIC Alloplastic Bone Grafting System is clinically proven with over 250,000 applications worldwide2. The safety and efficacy of the GUIDOR easy-graft has been documented in clinical research and in private practice patients.

Recent Publications
Leventis MD, Fairbairn P, Kakar A, Leventis AD, Margaritis V, Lückerath W, Horowitz RA, Rao BH, Lindner A, and Nagursky H. Minimally Invasive Alveolar Ridge Preservation Utilizing an In Situ Hardening β-TCP Bone Substitute: A multicenter Case Series. Int. J. Dent. 2016.

Schneider D, Schmidlin P R, Philipp A, Annen B M, Ronay V, Hämmerle C H, Attin T and Jung R E. Labial soft tissue volume evaluation of different techniques for ridge preservation after tooth extraction: a randomized controlled clinical trial J Clin Periodontol (2014) 41(6): 612-617.

Troedhan A, Kurrek A, Wainwright M, Schlichting I, Fischak-Treitl B and Ladentrog M. The transcrestal hydrodynamic ultrasonic cavitational sinuslift: Results of a 2-year prospective multicentre study on 404 patients, 446 sinuslift sites and 637 inserted implants. Open Journal of Stomatology (2013) 3: 471.

For a more extensive list of scientific publications, visit Scientific Publications for GUIDOR easy-graft

  1. Leventis, Minas, DDS. Socket Preservation using in situ hardening synthetic Bone Graft Substitute.
  2. Data on File. Sunstar Degradable solutions AG.


Each unit of GUIDOR® easy-graft® contains 3 systems.

Available in three sizes, each unit contains three systems of the same size. A system of GUIDOR® easy-graft® CLASSIC Alloplastic Bone Grafting System contains one syringe of coated granules and one ampule of BioLinker®.

Product Size Color Code Item # Granule Size Granule Net Volume Content per Unit
Large C11-008 500 - 1000μm 0.4 ml 3 systems
Medium C11-078 500 - 1000μm 0.25 ml 3 systems
Small C11-018 500 - 630μm 0.15 ml 3 systems

Size Selector – How much GUIDOR easy-graft is needed to fill a socket?

The following estimates are based on GUIDOR easy-graft placement in dentiform sockets. Material needs in clinical use may vary.

GUIDOR® easy-graft® material is available in Large, Medium and Small.